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PF 429242

CAS No. 947303-87-9

PF 429242( PF-429242 | PF 429242 | PF429242 )

Catalog No. M17686 CAS No. 947303-87-9

PF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM).

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF 429242
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM).
  • Description
    PF-429242 is a competitive inhibitor of sterol regulatory element-binding protein (SREBP) site 1 protease (IC50 = 0.175 μM). It is selective for site 1 protease against a panel of serine proteases. PF-429242 inhibits rate of cholesterol synthesis in CHO cells (IC50 = 0.53 μM).
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    PF-429242 | PF 429242 | PF429242
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    GPR
  • Recptor
    SREBP1
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    947303-87-9
  • Formula Weight
    482.49
  • Molecular Formula
    C25H35N3O2·2HCl
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C(c1ccc(CN(CC)CC)cc1)N(CCc1ccccc1OC)[C@@H]1CCNC1.Cl.Cl
  • Chemical Name
    (R)-4-((diethylamino)methyl)-N-(2-methoxyphenethyl)-N-(pyrrolidin-3-yl)benzamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Monnerie H, Romer M, Jensen BK, Millar JS, Jordan-Sciutto KL, Kim SF, Grinspan JB. Reduced sterol regulatory element-binding protein (SREBP) processing through site-1 protease (S1P) inhibition alters oligodendrocyte differentiation in vitro. J Neurochem.
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